WikiLeaks Show That Cannabis Kills Cancer

WikiLeaks Show That Cannabis Kills Cancer

Originally published on Dec 5, 2014 by Marijuana Health Facts “WikiLeaks that Show Marijuana Kills Cancer Cells”
“THC causes brain cancer cells to eat themselves. Natural products which have potential antitumor activities have become a focus of attention for study in previous years. Cannabinoids, the active components naturally derived from the marijuana plant Cannabis sativa L., have been reported as potential antitumor drugs based on their ability to limit inflammation, cell proliferation and cell survival.

“To date, several cannabinoids have been identified and characterized, including Δ(9)-tetrahydrocannabinol (THC), cannabidiol, cannabinol (CBN) and anandamide, as well as synthetic cannabinoids, including WIN-55,212-2, JWH-133 and (R)-methanandamide. In the early 1970s, THC and CBN were shown to inhibit tumor growth in Lewis lung carcinoma. Subsequently, cannabinoids were found to induce apoptosis and inhibit the proliferation of various cancer cells, including those of glioma and lymphoma, and prostate, breast, skin and pancreatic cancer.”

“Previous studies have speculated about the possible mechanisms responsible for the physiological and behavioral effects of cannabinoids. There is a view that cannabinoids exert their diversified activities via the activation of G-protein-coupled receptors which are normally bound by endocannabinoids. Two types of receptors, CB1 and CB2, have been cloned and characterized from mammalian tissues.”

“CB1 and CB2 are primarily expressed in the brain and immune system, respectively. Another viewpoint states that cannabinoids suppress tumor cell growth and induce apoptosis by modulating different cell signaling pathways and the expression of associated molecules, such as downregulating phosphoinositide 3-kinase (PI3K), protein kinases, extracellular signal-regulated kinase (ERK) signaling pathways and cell division cycle gene 2 (Cdc2), coupled with an activation of the proapoptotic function of Bad protein and small guanosine triphosphatase. An effect on the stress-regulated protein p8 and its downstream targets has also been identified as a mechanism of the antitumor action of THC”

Supporting documents and scientific research:

Antineoplastic Activity of Cannabinoids
http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/index.php

Cannabinoid Receptor Ligands Mediate Growth Inhibition & Cell Death In Mantle Cell Lymphoma
http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2005.11.020/full

Δ9-Tetrahydrocannabinol Induces Apoptosis in Human Prostate PC-3 Cells via a Receptor-Independent Mechanism
http://onlinelibrary.wiley.com/doi/10.1016/S0014-5793(99)01073-X/full

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
http://jpet.aspetjournals.org/content/318/3/1375.full

Cannabinoid Receptors As Novel Targets for the Treatment of Melanoma
http://bbml.ucm.es/cannabis/archivos/publicaciones/FASEB_J06_20_2633_2635.pdf

Cannabinoids Down-Regulate PI3K/Akt and Erk Signalling Pathways & Activate Proapoptotic Function of Bad Protein
http://www.medicinalgenomics.com/wp-content/uploads/2011/12/Cannabinoids-down-regulate-PI3K.pdf

Other Sources:
Pot Shrinks Tumors; Government Knew in ’74
http://www.alternet.org/story/9257/pot_shrinks_tumors%3B_government_knew_in_’74

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